HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PICAL (Q13492)
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
Gene: PICALM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0048261 - negative regulation of receptor-mediated endocytosis
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 652
+	Hs
		564516 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		545359 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		1036477 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		892355 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		950976 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		893978 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PICAL_HUMAN (1-652): 0: 606: 100.00
+	Hs
		124392 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HIP1_HUMAN (10-299): 3.19e-82: 281: 14.61
+	Hs
		297823 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297812 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297840 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297819 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297827 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297820 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28
+	Hs
		297809 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		K0754_HUMAN (269-648): 1.83e-22: 105: 10.28