HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: GIT2 (Q14161)
ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
Gene: GIT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 759
+	Hs
		564527 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00
+	Hs
		545371 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00
+	Hs
		1050152 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GIT2_HUMAN (1-759): 5.12e-178: 530: 100.00
+	Hs
		925751 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Gg
		1154344 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		Q9DG15_CHICK (1-758): 1.05e-140: 433: 64.96
+	Hs
		564752 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Hs
		545710 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Hs
		1331002 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GIT1_HUMAN (1-758): 7.22e-141: 434: 63.74
+	Hs
		925724 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ASAP1_HUMAN (3-656): 2.66e-63: 231: 15.57
+	Hs
		925736 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP1_HUMAN (3-224): 1.19e-59: 218: 33.33
+	Hs
		925551 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP2_HUMAN (3-224): 2.94e-54: 204: 32.00
+	Hs
		925478 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP2_HUMAN (7-186): 2.94e-51: 196: 32.24
+	Hs
		545580 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		AGAP2_HUMAN (3-224): 2.94e-54: 204: 32.00
+	Hs
		925529 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP1_HUMAN (8-186): 3.24e-49: 190: 30.22
+	Hs
		925238 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK3_HUMAN (95-437): 2.74e-48: 187: 12.75
+	Hs
		925204 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK2_HUMAN (108-437): 3.9e-45: 177: 13.13
+	Hs
		950953 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ANK3_HUMAN (95-437): 2.74e-48: 187: 12.75
+	Hs
		925681 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAI14_HUMAN (120-504): 2.87e-16: 85.4: 16.58
+	Hs
		564714 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RAI14_HUMAN (120-504): 2.87e-16: 85.4: 16.58
+	Hs
		1330959 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		RAI14_HUMAN (120-504): 2.87e-16: 85.4: 16.58