HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: LBR (Q14739)
Delta(14)-sterol reductase LBR (Delta-14-SR) (EC 1.3.1.70) (3-beta-hydroxysterol Delta (14)-reductase) (C-14 sterol reductase) (C14SR) (Integral nuclear envelope inner membrane protein) (LMN2R) (Lamin-B receptor) (Sterol C14-reductase)
Gene: LBR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 31871319, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 615
+	Hs
		545383 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		1058818 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		892377 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		951000 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		894018 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		900478 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		436305 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		LBR_HUMAN (1-615): 0: 914: 100.00
+	Hs
		925696 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		564719 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		545679 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		1330969 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		892655 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		951430 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		894549 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		901010 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00
+	Hs
		436556 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		DHCR7_HUMAN (203-615): 5.78e-169: 491: 34.00