HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: M3K11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Gene: MAP3K11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	9427749, 31871319
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 847
+	Hs
		545402 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		M3K11_HUMAN (1-847): 0: 649: 100.00
+	Hs
		892395 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		M3K11_HUMAN (1-847): 0: 649: 100.00
+	Hs
		951023 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		M3K11_HUMAN (1-847): 0: 649: 100.00
+	Hs
		894058 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		M3K11_HUMAN (1-847): 0: 649: 100.00
+	Hs
		925212 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		893917 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		892422 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Dm
		776899 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		M3KSL_DROME (43-633): 6.46e-124: 403: 43.21
+	Dm
		776934 CDC42_DROME (1-192): 2.41e-77: 231: 70.83		M3KSL_DROME (43-633): 6.46e-124: 403: 43.21
+	Dm
		816383 RHO1_DROME (5-192): 2.78e-75: 226: 59.04		M3KSL_DROME (43-633): 6.46e-124: 403: 43.21
+	Hs
		199540 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		M3K13_HUMAN (85-781): 7.92e-121: 390: 25.91
+	Hs
		893935 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ACK1_HUMAN (61-847): 1.02e-118: 386: 20.77
+	Rn
		1137281 CDC42_RAT (1-192): 1.4e-78: 234: 70.31		ACK1_RAT (55-847): 5.53e-116: 379: 21.52
+	Dm
		87957 RHO1_DROME (5-192): 2.78e-75: 226: 59.04		D3DMF6_DROME (110-683): 8.43e-119: 384: 27.00
+	Hs
		894512 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		M3K20_HUMAN (114-461): 3.54e-113: 365: 37.11
+	Hs
		789109 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FRK_HUMAN (113-377): 1.3e-100: 323: 34.06