HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG44 (Q17R89)
Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)
Gene: ARHGAP44

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	32203420, 11431473
Identification Methods	fluorescent resonance energy transfer, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005829 - cytosol GO:0032956 - regulation of actin cytoskeleton organization GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 818
+	Hs
		925354 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG17_HUMAN (1-816): 1.66e-117: 378: 44.34
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (5-434): 1.11e-88: 290: 17.38
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (30-429): 4.28e-88: 288: 17.93
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (10-686): 4.56e-82: 283: 15.93
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (30-429): 8.69e-84: 277: 16.94
+	Hs
		245184 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OPHN1_HUMAN (11-675): 1.13e-79: 275: 16.19
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (231-775): 5.81e-73: 262: 20.11
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (12-710): 4.72e-73: 261: 14.75
+	Hs
		253337 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP2_HUMAN (12-782): 1.01e-71: 256: 15.15
+	Hs
		925192 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG04_HUMAN (108-683): 2.32e-71: 254: 17.63
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (223-748): 1.81e-69: 252: 20.14
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (47-467): 9.51e-69: 250: 16.98
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (102-734): 7.8e-67: 244: 17.73
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (150-690): 2.11e-68: 241: 19.18
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (178-429): 1.06e-71: 240: 20.00
+	Hs
		925394 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG22_HUMAN (253-429): 1.03e-23: 108: 38.25
+	Hs
		925227 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG01_HUMAN (268-414): 6.18e-18: 89.4: 34.46
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (267-413): 3.14e-17: 89: 36.91
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (231-449): 5.92e-17: 88.2: 28.76
+	Mm
		925791 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG01_MOUSE (268-414): 5.66e-17: 86.3: 33.11