HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: DOC11 (Q5JSL3)
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)
Gene: DOCK11

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2073
+	Hs
		564557 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOC11_HUMAN (1-2073): 0: 2784: 100.00
+	Hs
		545421 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOC11_HUMAN (1-2073): 0: 2784: 100.00
+	Hs
		1127531 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOC11_HUMAN (1-2073): 0: 2784: 100.00
+	Hs
		925588 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK9_HUMAN (2-2035): 0: 2538: 58.90
+	Hs
		564671 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOCK9_HUMAN (2-2035): 0: 2538: 58.90
+	Hs
		545596 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK9_HUMAN (2-2035): 0: 2538: 58.90
+	Hs
		1317682 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOCK9_HUMAN (2-2035): 0: 2538: 58.90
+	Hs
		925429 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK4_HUMAN (1464-2069): 9.01e-156: 532: 17.36
+	Hs
		925425 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK3_HUMAN (394-1146): 6.86e-111: 396: 13.56
+	Mm
		925807 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		DOCK1_MOUSE (252-1145): 2.15e-98: 356: 14.47
+	Hs
		925276 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK1_HUMAN (252-1226): 5.97e-97: 351: 13.50
+	Hs
		545372 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK1_HUMAN (252-1226): 5.97e-97: 351: 13.50
+	Hs
		925486 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK2_HUMAN (394-1141): 1.61e-91: 333: 14.93
+	Hs
		545535 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK2_HUMAN (394-1141): 1.61e-91: 333: 14.93
+	Hs
		925620 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK5_HUMAN (394-1145): 7.57e-71: 267: 14.75
+	Hs
		545622 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK5_HUMAN (394-1145): 7.57e-71: 267: 14.75
+	Hs
		925526 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK7_HUMAN (1-163): 4.93e-49: 195: 31.18
+	Hs
		925518 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK6_HUMAN (2-156): 1.83e-42: 174: 30.54
+	Hs
		925448 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK8_HUMAN (2-147): 1.58e-39: 164: 22.70
+	Dm
		776892 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q8MQW7_DROME (882-1151): 3.09e-11: 71: 11.38