HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PREX2 (Q70Z35)
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2)
Gene: PREX2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PDZ~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1606
+	Hs
		925455 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX1_HUMAN (4-1600): 0: 1874: 56.86
+	Hs
		925374 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DNMBP_HUMAN (7-617): 2.5e-86: 314: 17.16
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (2-435): 5.45e-91: 312: 30.12
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (6-409): 1.69e-87: 303: 30.79
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (3-439): 1.18e-81: 290: 22.44
+	Hs
		925241 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TIAM1_HUMAN (2-530): 2.31e-78: 289: 18.69
+	Hs
		50580 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG3_HUMAN (1-442): 8.9e-79: 288: 23.53
+	Hs
		500934 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MCF2_HUMAN (4-480): 4.6e-80: 287: 19.47
+	Hs
		564502 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		TIAM1_HUMAN (2-530): 2.31e-78: 289: 18.69
+	Hs
		925727 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHG1_HUMAN (4-537): 5.67e-78: 287: 19.15
+	Hs
		50555 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHG3_HUMAN (1-442): 8.9e-79: 288: 23.53
+	Hs
		564737 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHG1_HUMAN (4-537): 5.67e-78: 287: 19.15
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (19-412): 4.52e-78: 280: 25.25
+	Rn
		88818 RAC1_RAT (1-192): 3.81e-86: 253: 100.00		D3ZWV8_RAT (9-398): 1.05e-72: 271: 22.38
+	Mm
		925795 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		TIAM1_MOUSE (9-398): 1.46e-72: 270: 22.38
+	Hs
		166482 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MCF2L_HUMAN (1-408): 1.95e-72: 267: 21.80
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (27-359): 3.82e-74: 266: 24.11
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (27-359): 3.82e-74: 266: 24.11
+	Hs
		925718 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV3_HUMAN (12-354): 1.08e-71: 260: 24.13
+	Ce
		975575 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		VAV_CAEEL (28-351): 1.99e-20: 100: 26.50