HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: UBE3B (Q7Z3V4)
Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
Gene: UBE3B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	27173435
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1068
+	Hs
		808080 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NEDD4_HUMAN (604-1066): 1.95e-158: 505: 28.54
+	Hs
		925520 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		564644 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125349 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		545560 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125140 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		1294861 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125135 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		892540 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		951237 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		1299636 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		NED4L_HUMAN (604-1066): 8.92e-159: 497: 27.68
+	Hs
		894313 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ITCH_HUMAN (604-1066): 1.43e-161: 502: 28.02
+	Hs
		125711 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		125294 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		125372 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		125298 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		WWP2_HUMAN (655-1066): 5.73e-159: 494: 29.30
+	Hs
		925397 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HUWE1_HUMAN (608-1068): 7.34e-141: 471: 30.02
+	Mm
		56825 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		SMUF2_MOUSE (646-1065): 5.31e-151: 469: 27.73
+	Hs
		925423 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HACE1_HUMAN (622-1063): 2.02e-142: 452: 28.54
+	Rn
		88544 RHOA_RAT (5-192): 1.43e-77: 231: 57.98		D3ZCF5_RAT (641-1065): 2.47e-150: 466: 27.64