HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: DSG4 (Q86SJ6)
Desmoglein-4 (Cadherin family member 13)
Gene: DSG4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1040
+	Hs
		925270 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		564523 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		545367 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		1048664 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		892364 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		950987 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		DSG2_HUMAN (5-1027): 0: 795: 35.05
+	Hs
		925210 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		564486 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		545331 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		971065 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		564530 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DSC3_HUMAN (21-847): 0: 678: 28.11
+	Hs
		892326 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		950934 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		DSC2_HUMAN (7-850): 0: 691: 29.85
+	Hs
		1055855 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DSC3_HUMAN (21-847): 0: 678: 28.11
+	Hs
		521837 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		CADH1_HUMAN (26-599): 5.48e-179: 546: 32.14
+	Hs
		580220 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CADH2_HUMAN (157-617): 1.01e-38: 158: 15.72
+	Hs
		545200 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		CADH2_HUMAN (157-617): 1.01e-38: 158: 15.72
+	Hs
		580261 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		CADH2_HUMAN (157-617): 1.01e-38: 158: 15.72
+	Hs
		580218 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		CADH2_HUMAN (157-617): 1.01e-38: 158: 15.72
+	Hs
		580224 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		CADH2_HUMAN (157-617): 1.01e-38: 158: 15.72