HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ARHGJ (Q8IW93)
Rho guanine nucleotide exchange factor 19 (Ephexin-2)
Gene: ARHGEF19

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18256687
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0032956 - regulation of actin cytoskeleton organization GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 802
+	Hs
		925436 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NGEF_HUMAN (113-790): 8e-124: 389: 31.41
+	Hs
		925512 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGQ_HUMAN (5-792): 1.53e-117: 377: 25.83
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (147-711): 2.31e-102: 331: 12.74
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (102-743): 1.3e-99: 325: 13.38
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (271-737): 1.17e-93: 313: 15.42
+	Hs
		925624 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ECT2_HUMAN (246-801): 6.02e-92: 310: 17.78
+	Hs
		167081 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGB_HUMAN (128-743): 1.07e-84: 297: 14.86
+	Hs
		925760 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Hs
		564756 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (270-737): 4.44e-85: 291: 14.23
+	Hs
		892637 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		ARHGC_HUMAN (187-750): 6.75e-88: 306: 14.58
+	Hs
		925382 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX2_HUMAN (362-716): 1.22e-81: 288: 16.40
+	Dm
		776905 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q9U7D8_DROME (382-732): 1.49e-86: 294: 20.88
+	Hs
		545718 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Dm
		819746 RAC2_DROME (1-192): 2.18e-81: 241: 89.58		Q9U7D8_DROME (382-732): 1.49e-86: 294: 20.88
+	Hs
		1331006 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Hs
		951489 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		FARP1_HUMAN (134-762): 1.08e-84: 293: 14.99
+	Hs
		951099 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PREX2_HUMAN (362-716): 1.22e-81: 288: 16.40
+	Hs
		224711 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KALRN_HUMAN (365-801): 9.95e-72: 259: 14.77
+	Sp
		963942 CDC42_SCHPO (1-192): 9.82e-82: 242: 68.23		RGF1_SCHPO (332-699): 1.09e-74: 267: 20.60