HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: DOCK3 (Q8IZD9)
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)
Gene: DOCK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2030
+	Hs
		925429 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK4_HUMAN (1-1996): 0: 2003: 54.58
+	Hs
		925486 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK2_HUMAN (2-1771): 0: 1932: 36.29
+	Hs
		545535 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK2_HUMAN (2-1771): 0: 1932: 36.29
+	Mm
		925807 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		DOCK1_MOUSE (2-1855): 0: 1914: 37.08
+	Hs
		925276 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		545372 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		925620 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Hs
		545622 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Dm
		776892 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q8MQW7_DROME (654-1851): 0: 1037: 29.75
+	Hs
		925588 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK9_HUMAN (235-955): 0: 637: 13.65
+	Hs
		564671 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOCK9_HUMAN (235-955): 0: 637: 13.65
+	Hs
		545596 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK9_HUMAN (235-955): 0: 637: 13.65
+	Hs
		925332 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOC11_HUMAN (857-1671): 0: 625: 14.24
+	Hs
		1317682 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOCK9_HUMAN (235-955): 0: 637: 13.65
+	Hs
		564557 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOC11_HUMAN (857-1671): 0: 625: 14.24
+	Hs
		545421 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOC11_HUMAN (857-1671): 0: 625: 14.24
+	Hs
		1127531 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOC11_HUMAN (857-1671): 0: 625: 14.24
+	Hs
		925526 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK7_HUMAN (248-964): 1.22e-166: 565: 16.56
+	Hs
		925518 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK6_HUMAN (242-957): 3.47e-154: 528: 13.88
+	Hs
		925448 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK8_HUMAN (723-957): 5.88e-31: 136: 8.98