HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: NGEF (Q8N5V2)
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Gene: NGEF

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18256687
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 710
+	Hs
		925512 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGQ_HUMAN (20-691): 1.64e-119: 380: 27.26
+	Hs
		925416 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGJ_HUMAN (10-691): 1.19e-115: 368: 30.24
+	Hs
		925527 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SPT13_HUMAN (37-630): 3.84e-102: 328: 14.08
+	Hs
		925649 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG4_HUMAN (9-644): 1.24e-101: 328: 15.36
+	Hs
		548678 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV_HUMAN (152-709): 1.25e-98: 324: 15.87
+	Hs
		167081 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHGB_HUMAN (3-708): 5.04e-93: 318: 15.16
+	Hs
		925718 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV3_HUMAN (167-708): 6.57e-93: 309: 12.16
+	Hs
		925382 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX2_HUMAN (251-614): 2.77e-86: 299: 19.48
+	Hs
		925624 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ECT2_HUMAN (146-681): 1.79e-88: 298: 15.87
+	Hs
		855782 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		VAV2_HUMAN (167-682): 4.63e-88: 296: 13.88
+	Hs
		925271 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARHG7_HUMAN (26-628): 1.28e-87: 294: 12.22
+	Hs
		564524 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ARHG7_HUMAN (26-628): 1.28e-87: 294: 12.22
+	Hs
		925455 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PREX1_HUMAN (223-613): 3.34e-83: 290: 19.66
+	Hs
		156397 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RGRF2_HUMAN (76-598): 4.72e-83: 288: 15.48
+	Hs
		545368 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		ARHG7_HUMAN (26-628): 1.28e-87: 294: 12.22
+	Hs
		951099 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PREX2_HUMAN (251-614): 2.77e-86: 299: 19.48
+	Hs
		1049733 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ARHG7_HUMAN (26-628): 1.28e-87: 294: 12.22
+	Hs
		279854 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TRIO_HUMAN (262-658): 2.58e-58: 216: 19.19
+	Hs
		224711 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KALRN_HUMAN (262-672): 7.64e-57: 212: 18.87
+	Hs
		279855 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		TRIO_HUMAN (262-658): 2.58e-58: 216: 19.19