HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	19277120
Identification Methods	fluorescent resonance energy transfer, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0030027 - lamellipodium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 591
+	Mm
		925824 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		HOME2_MOUSE (1-299): 1.53e-66: 222: 19.41
+	Hs
		1191573 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		SPRE1_HUMAN (2-314): 1.71e-57: 201: 18.58
+	Hs
		925434 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MINK1_HUMAN (113-575): 1.26e-34: 142: 15.12
+	Hs
		564611 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MINK1_HUMAN (113-575): 1.26e-34: 142: 15.12
+	Mm
		925783 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		TNIK_MOUSE (90-575): 1.04e-33: 139: 14.08
+	Hs
		545493 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MINK1_HUMAN (113-575): 1.26e-34: 142: 15.12
+	Hs
		1233542 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MINK1_HUMAN (113-575): 1.26e-34: 142: 15.12
+	Hs
		892483 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MINK1_HUMAN (113-575): 1.26e-34: 142: 15.12
+	Ce
		136793 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		UNC89_CAEEL (112-571): 5.62e-26: 116: 9.91
+	Hs
		160190 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		HGS_HUMAN (90-385): 6.31e-28: 120: 22.22
+	Mm
		82719 RAC3_MOUSE (1-191): 2.72e-79: 236: 93.19		CTTB2_MOUSE (87-571): 1.13e-28: 124: 11.52
+	Hs
		892610 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		MYO10_HUMAN (182-480): 4.53e-25: 112: 14.15
+	Hs
		925705 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SWP70_HUMAN (84-269): 5.97e-14: 76.9: 25.00
+	Hs
		297823 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		K0754_HUMAN (249-591): 1.4e-12: 73.4: 10.63
+	Hs
		545684 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		SWP70_HUMAN (84-269): 5.97e-14: 76.9: 25.00
+	Hs
		297812 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		K0754_HUMAN (249-591): 1.4e-12: 73.4: 10.63
+	Hs
		297840 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		K0754_HUMAN (249-591): 1.4e-12: 73.4: 10.63
+	Hs
		892662 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		SWP70_HUMAN (84-269): 5.97e-14: 76.9: 25.00
+	Hs
		297819 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		K0754_HUMAN (249-591): 1.4e-12: 73.4: 10.63
+	Hs
		297827 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		K0754_HUMAN (249-591): 1.4e-12: 73.4: 10.63