HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RIT1 (Q92963)
GTP-binding protein Rit1 (EC 3.6.5.2) (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)
Gene: RIT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	29734338
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0003925 - G protein activity GO:0005525 - GTP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 219
+	Hs
		918847 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAB1A_HUMAN (11-218): 4.01e-82: 245: 28.23
+	Hs
		895028 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAB2A_HUMAN (17-219): 8.04e-82: 244: 32.35
+	Hs
		564470 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RAB1A_HUMAN (11-218): 4.01e-82: 245: 28.23
+	Hs
		925305 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RB11B_HUMAN (11-210): 2.93e-81: 243: 27.59
+	Hs
		925600 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAB1B_HUMAN (14-217): 3.36e-79: 237: 26.83
+	Hs
		545307 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RAB1A_HUMAN (11-218): 4.01e-82: 245: 28.23
+	Hs
		545297 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RAB2A_HUMAN (17-219): 8.04e-82: 244: 32.35
+	Hs
		894716 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAB8A_HUMAN (14-217): 8.93e-78: 233: 29.27
+	Hs
		913995 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RB11A_HUMAN (11-218): 1.48e-77: 233: 26.64
+	Hs
		564466 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RAB8A_HUMAN (14-217): 8.93e-78: 233: 29.27
+	Hs
		545295 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RAB8A_HUMAN (14-217): 8.93e-78: 233: 29.27
+	Hs
		545305 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RB11A_HUMAN (11-218): 1.48e-77: 233: 26.64
+	Hs
		897878 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RAP1B_HUMAN (20-197): 9.5e-57: 179: 49.16
+	Hs
		564467 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RAP1B_HUMAN (20-197): 9.5e-57: 179: 49.16
+	Hs
		545300 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RAP1B_HUMAN (20-197): 9.5e-57: 179: 49.16
+	Hs
		905413 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RRAS2_HUMAN (21-201): 4.46e-52: 168: 52.75
+	Hs
		564468 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RRAS2_HUMAN (21-201): 4.46e-52: 168: 52.75
+	Hs
		545304 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RRAS2_HUMAN (21-201): 4.46e-52: 168: 52.75
+	Hs
		350049 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RASK_HUMAN (21-195): 1.28e-47: 156: 50.29
+	Hs
		349848 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RASK_HUMAN (21-195): 1.28e-47: 156: 50.29