HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33545068
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005802 - trans-Golgi network GO:0005829 - cytosol GO:0055038 - recycling endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 577
+	Hs
		925488 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		925322 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		148653 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		564633 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		564553 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		545537 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MY18A_HUMAN (73-548): 2.87e-14: 78.5: 12.99
+	Hs
		254468 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		545414 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		254445 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		724757 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08
+	Mm
		823530 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CTRO_MOUSE (55-542): 5.99e-10: 64.7: 10.61
+	Hs
		1113848 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		925766 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		564758 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		725138 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH10_HUMAN (233-561): 3.51e-13: 74.9: 10.88
+	Hs
		254512 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		545725 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		254472 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22
+	Hs
		1331011 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		724776 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		MYH9_HUMAN (171-574): 4.74e-10: 64.8: 13.08