HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: DOCK6 (Q96HP0)
Dedicator of cytokinesis protein 6
Gene: DOCK6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2047
+	Hs
		925526 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK7_HUMAN (4-2047): 0: 2404: 64.55
+	Hs
		925448 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK8_HUMAN (1-2046): 0: 2393: 51.47
+	Dm
		776892 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q8MQW7_DROME (1422-2042): 2e-151: 506: 16.74
+	Mm
		925807 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		DOCK1_MOUSE (299-908): 6.93e-115: 408: 17.00
+	Hs
		925276 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK1_HUMAN (299-908): 1.29e-113: 404: 17.00
+	Hs
		545372 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK1_HUMAN (299-908): 1.29e-113: 404: 17.00
+	Hs
		925429 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK4_HUMAN (338-908): 5.37e-85: 312: 18.72
+	Hs
		925425 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK3_HUMAN (298-908): 8.52e-78: 289: 17.24
+	Hs
		925620 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK5_HUMAN (299-908): 7.31e-73: 273: 15.42
+	Hs
		545622 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK5_HUMAN (299-908): 7.31e-73: 273: 15.42
+	Hs
		925486 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK2_HUMAN (296-908): 1.9e-68: 259: 14.90
+	Hs
		545535 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK2_HUMAN (296-908): 1.9e-68: 259: 14.90
+	Hs
		925588 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK9_HUMAN (2-275): 4.4e-46: 185: 20.07
+	Hs
		564671 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOCK9_HUMAN (2-275): 4.4e-46: 185: 20.07
+	Hs
		925332 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOC11_HUMAN (4-169): 2.14e-44: 180: 30.23
+	Hs
		564557 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOC11_HUMAN (4-169): 2.14e-44: 180: 30.23
+	Hs
		545596 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK9_HUMAN (2-275): 4.4e-46: 185: 20.07
+	Hs
		1317682 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOCK9_HUMAN (2-275): 4.4e-46: 185: 20.07
+	Hs
		545421 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOC11_HUMAN (4-169): 2.14e-44: 180: 30.23
+	Hs
		1127531 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		DOC11_HUMAN (4-169): 2.14e-44: 180: 30.23