HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: DOCK9 (Q9BZ29)
Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1)
Gene: DOCK9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, PH~Ras
Common GO terms	GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2069
+	Hs
		564671 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOCK9_HUMAN (1-2069): 0: 2505: 100.00
+	Hs
		925332 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOC11_HUMAN (11-2068): 0: 2189: 58.38
+	Hs
		564557 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		DOC11_HUMAN (11-2068): 0: 2189: 58.38
+	Hs
		545421 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOC11_HUMAN (11-2068): 0: 2189: 58.38
+	Mm
		925807 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		DOCK1_MOUSE (395-1220): 0: 621: 14.22
+	Hs
		925276 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK1_HUMAN (395-1220): 0: 616: 13.87
+	Hs
		545372 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK1_HUMAN (395-1220): 0: 616: 13.87
+	Hs
		925429 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK4_HUMAN (395-1225): 3.36e-176: 591: 14.85
+	Hs
		925486 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK2_HUMAN (395-1220): 3.51e-175: 585: 13.09
+	Hs
		545535 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DOCK2_HUMAN (395-1220): 3.51e-175: 585: 13.09
+	Hs
		925620 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK5_HUMAN (395-1224): 1.09e-163: 553: 13.46
+	Hs
		925425 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK3_HUMAN (395-1225): 1.76e-145: 503: 14.53
+	Hs
		925254 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GAB1_HUMAN (171-470): 2.06e-66: 242: 17.39
+	Hs
		564515 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GAB1_HUMAN (171-470): 2.06e-66: 242: 17.39
+	Dm
		776892 RAC1_DROME (1-192): 8.65e-83: 245: 91.67		Q8MQW7_DROME (885-1230): 5.09e-52: 204: 13.04
+	Hs
		925526 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK7_HUMAN (11-205): 1.33e-48: 194: 24.88
+	Hs
		925518 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK6_HUMAN (9-176): 1.25e-43: 177: 23.37
+	Hs
		925448 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DOCK8_HUMAN (7-167): 4.89e-42: 172: 21.23
+	Hs
		925632 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHA1_HUMAN (149-366): 8.42e-36: 143: 18.83
+	Hs
		564691 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHA1_HUMAN (149-366): 8.42e-36: 143: 18.83