HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 779
+	Hs
		925254 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		564515 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		925738 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TBD2B_HUMAN (53-512): 3.31e-51: 195: 17.57
+	Hs
		925241 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		925615 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OSBL3_HUMAN (52-563): 4.71e-44: 173: 11.36
+	Hs
		564502 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		564562 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		RHG21_HUMAN (22-662): 1.96e-43: 172: 13.18
+	Hs
		925705 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SWP70_HUMAN (55-446): 3.06e-44: 170: 11.36
+	Mm
		925795 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		TIAM1_MOUSE (2-634): 2.04e-40: 163: 12.13
+	Rn
		88818 RAC1_RAT (1-192): 3.81e-86: 253: 100.00		D3ZWV8_RAT (2-634): 1.21e-39: 160: 11.65
+	Hs
		925632 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		925629 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		564691 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHA1_HUMAN (16-261): 3.76e-39: 151: 16.92
+	Hs
		564690 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		925394 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG22_HUMAN (29-181): 1.62e-33: 139: 26.95
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (33-181): 1.33e-31: 133: 25.77
+	Hs
		925760 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FARP1_HUMAN (6-167): 1.07e-24: 112: 17.96
+	Hs
		925603 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21
+	Hs
		564677 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		TARA_HUMAN (49-471): 7.83e-20: 97.3: 15.21