HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016477 - cell migration GO:0034446 - substrate adhesion-dependent cell spreading
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1746
+	Hs
		564687 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		545621 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		1330919 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		892599 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		951343 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		894437 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		900910 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		436511 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		PEAK1_HUMAN (1-1746): 0: 2185: 100.00
+	Hs
		681775 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AKT1_HUMAN (1362-1695): 4.43e-91: 307: 15.07
+	Hs
		568619 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568794 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568605 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		568611 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		436148 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		KAPCA_HUMAN (1345-1709): 1.06e-90: 301: 18.30
+	Hs
		900861 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		PINK1_HUMAN (1357-1669): 2.87e-73: 258: 23.64
+	Hs
		616691 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		KS6B1_HUMAN (1453-1683): 8.42e-45: 173: 16.17
+	Ce
		136793 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		104464 G5EBV3_CAEEL (2-192): 6.22e-78: 232: 65.45		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136794 CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80
+	Ce
		136800 RHO1_CAEEL (5-192): 4.91e-75: 225: 59.04		UNC89_CAEEL (530-1704): 6.06e-21: 103: 12.80