HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: IL1AP (Q9NPH3)
Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
Gene: IL1RAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	11416133, 31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0016020 - membrane GO:0098978 - glutamatergic synapse
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 570
+	Hs
		436525 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		IL1AP_HUMAN (1-570): 1.4e-118: 364: 100.00
+	Hs
		540389 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		IL1R1_HUMAN (67-566): 2.25e-77: 256: 22.39
+	Hs
		309818 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		I18RA_HUMAN (62-568): 2.5e-65: 225: 23.56
+	Hs
		925776 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		564764 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		1331019 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		894644 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		901110 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		436602 RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45		ROBO1_HUMAN (1-281): 7.3e-41: 161: 14.53
+	Hs
		894276 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		PXDN_HUMAN (138-492): 4.72e-34: 140: 11.14
+	Ce
		136793 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		UNC89_CAEEL (1-133): 7.87e-13: 74: 9.70
+	Ce
		104464 G5EBV3_CAEEL (2-192): 6.22e-78: 232: 65.45		UNC89_CAEEL (1-133): 7.87e-13: 74: 9.70
+	Hs
		894044 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		MYLK_HUMAN (24-131): 6.49e-12: 70.9: 16.67
+	Ce
		136794 CDC42_CAEEL (1-192): 5.89e-76: 227: 69.27		UNC89_CAEEL (1-133): 7.87e-13: 74: 9.70
+	Ce
		136800 RHO1_CAEEL (5-192): 4.91e-75: 225: 59.04		UNC89_CAEEL (1-133): 7.87e-13: 74: 9.70