HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: PAK5 (Q9P286)
Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7)
Gene: PAK5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11756552
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 719
+	Hs
		925648 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK6_HUMAN (1-718): 4.95e-171: 508: 44.37
+	Hs
		564425 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		AKT2_HUMAN (307-716): 2e-135: 409: 20.52
+	Hs
		681775 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AKT1_HUMAN (307-716): 1.36e-131: 399: 19.77
+	Ce
		975572 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		PK1_CAEEL (298-718): 1.38e-117: 366: 36.71
+	Hs
		850632 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KS6A3_HUMAN (386-714): 3.35e-112: 357: 22.41
+	Dd
		332055 RACF1_DICDI (1-179): 2.03e-96: 279: 72.63		PAKB_DICDI (430-717): 8.85e-66: 235: 45.21
+	Dd
		710119 RACA_DICDI (1-187): 1.11e-84: 263: 65.24		PAKB_DICDI (430-717): 8.85e-66: 235: 45.21
+	Hs
		330967 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK4_HUMAN (1-314): 7.21e-41: 160: 28.35
+	Hs
		330841 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK4_HUMAN (1-314): 7.21e-41: 160: 28.35
+	Mm
		925809 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		PAK2_MOUSE (8-176): 1.24e-31: 131: 18.68
+	Hs
		277602 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK3_HUMAN (3-189): 9.13e-31: 129: 19.43
+	Hs
		925245 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK2_HUMAN (8-157): 1.07e-30: 129: 20.99
+	Hs
		564507 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK2_HUMAN (8-157): 1.07e-30: 129: 20.99
+	Mm
		103566 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		G5E884_MOUSE (3-183): 1.21e-29: 125: 20.40
+	Mm
		103575 RHOQ_MOUSE (4-187): 8.33e-85: 250: 64.13		G5E884_MOUSE (3-183): 1.21e-29: 125: 20.40
+	Mm
		292040 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		PAK1_MOUSE (3-183): 2.49e-28: 122: 18.69
+	Hs
		925244 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK1_HUMAN (3-183): 1.54e-28: 122: 18.69
+	Hs
		564505 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK1_HUMAN (3-183): 1.54e-28: 122: 18.69
+	Mm
		103567 RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67		G5E884_MOUSE (3-183): 1.21e-29: 125: 20.40
+	Mm
		292041 RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67		PAK1_MOUSE (3-183): 2.49e-28: 122: 18.69