HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	19961560, 31871319, 36963288
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016020 - membrane GO:0030027 - lamellipodium GO:0044877 - protein-containing complex binding and 1 others more... GO:0098794 - postsynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 761
+	Hs
		564752 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		545710 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1331002 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Gg
		1154344 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		Q9DG15_CHICK (1-761): 2.03e-155: 471: 85.41
+	Hs
		925274 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		564527 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		545371 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		1050152 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		950990 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		925724 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		545454 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		POTEE_HUMAN (31-683): 6.72e-62: 227: 12.90
+	Hs
		925736 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Hs
		925423 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HACE1_HUMAN (134-500): 3.45e-54: 203: 15.80
+	Hs
		925551 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		925478 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP2_HUMAN (7-223): 6.18e-51: 195: 27.15
+	Hs
		545580 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		AGAP2_HUMAN (2-223): 3.67e-52: 198: 32.00
+	Hs
		925529 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ARAP1_HUMAN (8-205): 6.26e-49: 188: 29.35
+	Hs
		925238 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		950953 RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35		ANK3_HUMAN (93-695): 4.85e-40: 162: 12.34
+	Hs
		925204 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		ANK2_HUMAN (162-494): 7.25e-30: 129: 9.52