HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG01 (Q5FWK3)
Rho GTPase-activating protein 1 (Rho-type GTPase-activating protein 1)
Gene: Arhgap1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	14966113
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 439
+	Hs
		925227 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG01_HUMAN (1-439): 1.63e-155: 449: 96.58
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (167-437): 5.96e-76: 259: 22.74
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (208-433): 1.82e-70: 240: 22.61
+	Hs
		925394 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG22_HUMAN (138-438): 4.21e-71: 239: 23.36
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (138-437): 3.6e-71: 239: 24.06
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (148-431): 2.43e-67: 234: 20.46
+	Hs
		925420 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG12_HUMAN (196-432): 6.33e-68: 233: 22.50
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (190-433): 9.93e-66: 230: 22.39
+	Hs
		925489 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		HMHA1_HUMAN (184-431): 2.23e-65: 228: 23.55
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (206-434): 8.15e-65: 227: 25.42
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (182-438): 7.11e-65: 227: 25.94
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (206-431): 7.48e-69: 227: 23.28
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (168-436): 1.23e-68: 227: 20.94
+	Hs
		925354 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG17_HUMAN (212-434): 1.41e-65: 227: 25.33
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (180-434): 8.21e-65: 227: 21.85
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (206-431): 2.86e-69: 224: 23.28
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (206-431): 2.06e-66: 221: 23.28
+	Hs
		925319 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG31_HUMAN (234-431): 2.71e-62: 220: 26.32
+	Hs
		302639 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FA13A_HUMAN (242-431): 2.68e-25: 110: 34.54
+	Hs
		925671 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FA13B_HUMAN (237-401): 8.78e-18: 88.2: 31.95