HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG22 (Q8BL80)
Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22) (p68RacGAP)
Gene: Arhgap22

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	14966113
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 702
+	Hs
		245184 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		OPHN1_HUMAN (11-589): 3.98e-95: 313: 17.54
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (11-637): 6.08e-93: 309: 16.82
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (76-671): 1.69e-86: 300: 19.59
+	Hs
		925354 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG17_HUMAN (44-624): 7.95e-86: 290: 19.52
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (76-644): 1.11e-80: 279: 17.55
+	Hs
		925314 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG44_HUMAN (44-577): 2.65e-80: 274: 17.86
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (86-615): 1.71e-73: 261: 16.30
+	Hs
		253337 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP2_HUMAN (68-652): 1.08e-72: 257: 16.61
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (86-516): 8.23e-72: 256: 18.12
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (86-615): 8.39e-71: 253: 16.30
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (68-355): 2.94e-73: 246: 22.03
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (18-360): 6.15e-72: 243: 18.40
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (24-355): 2.32e-72: 239: 20.41
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (156-355): 3.29e-69: 235: 29.56
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (159-381): 6.79e-65: 235: 27.23
+	Hs
		925378 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG27_HUMAN (157-357): 4.77e-64: 230: 30.05
+	Hs
		925227 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG01_HUMAN (159-359): 9.96e-66: 225: 30.35
+	Mm
		925791 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG01_MOUSE (159-362): 1.44e-65: 225: 29.90
+	Hs
		302639 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		FA13A_HUMAN (179-361): 2.52e-20: 98.2: 35.68
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (157-342): 8.4e-20: 96.3: 31.75