HitPredict

Interactor 1: RAC1 (P63001)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Gene: RAC1

Interactor 2: PAK2 (Q8CIN4)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (p21-activated kinase 2) (PAK-2) [Cleaved into: PAK-2p27; PAK-2p34]
Gene: PAK2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15292195
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0019901 - protein kinase binding and 1 others more... GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 524
+	Hs
		925245 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK2_HUMAN (1-524): 0: 534: 97.14
+	Hs
		564507 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK2_HUMAN (1-524): 0: 534: 97.14
+	Mm
		103566 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		G5E884_MOUSE (1-523): 8.42e-171: 495: 72.93
+	Hs
		925244 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK1_HUMAN (1-523): 1e-170: 495: 73.35
+	Hs
		564505 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK1_HUMAN (1-523): 1e-170: 495: 73.35
+	Mm
		103575 RHOQ_MOUSE (4-187): 8.33e-85: 250: 64.13		G5E884_MOUSE (1-523): 8.42e-171: 495: 72.93
+	Mm
		292040 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		PAK1_MOUSE (1-523): 1.4e-168: 489: 72.24
+	Mm
		103567 RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67		G5E884_MOUSE (1-523): 8.42e-171: 495: 72.93
+	Mm
		292041 RAC2_MOUSE (1-192): 6.16e-83: 245: 91.67		PAK1_MOUSE (1-523): 1.4e-168: 489: 72.24
+	Hs
		277602 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK3_HUMAN (1-523): 1.66e-161: 472: 70.64
+	Dd
		332055 RACF1_DICDI (1-179): 2.03e-96: 279: 72.63		PAKB_DICDI (39-523): 3.6e-124: 385: 36.04
+	Hs
		564425 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		AKT2_HUMAN (79-523): 9.06e-140: 413: 20.93
+	Hs
		681775 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		AKT1_HUMAN (83-523): 1.06e-136: 405: 21.95
+	Ce
		975572 RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81		PK1_CAEEL (9-522): 4.16e-136: 407: 51.67
+	Dd
		710119 RACA_DICDI (1-187): 1.11e-84: 263: 65.24		PAKB_DICDI (39-523): 3.6e-124: 385: 36.04
+	Hs
		330967 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK4_HUMAN (1-519): 1.86e-129: 391: 33.65
+	Hs
		330841 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		PAK4_HUMAN (1-519): 1.86e-129: 391: 33.65
+	Hs
		568619 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		KAPCA_HUMAN (207-520): 6.66e-131: 386: 22.91
+	Hs
		925692 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK5_HUMAN (67-178): 3.24e-12: 71.1: 21.74
+	Hs
		925648 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		PAK6_HUMAN (65-127): 8.14e-11: 66.5: 38.10