HitPredict

Interactor 1: TLE5 (P63002)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG)
Gene: TLE5

Interactor 2: HMGB1 (P63158)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	11748221
Identification Methods	pull down, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 197 Mm			1 215
+	Hs
		449690 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		HMGB1_HUMAN (1-174): 6.46e-41: 140: 100.00
+	Mm
		927926 TLE1_MOUSE (2-197): 2.23e-98: 302: 63.00		HMGB1_MOUSE (1-174): 6.46e-41: 140: 100.00
+	Hs
		980847 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		CIC_HUMAN (57-210): 2.81e-30: 119: 19.48
+	Hs
		449697 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		HMGB1_HUMAN (1-174): 6.46e-41: 140: 100.00
+	Hs
		817954 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91
+	Hs
		980642 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SOX7_HUMAN (3-90): 3.17e-20: 89.4: 19.32
+	Hs
		980649 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SOX17_HUMAN (7-90): 3.32e-20: 89.4: 19.05
+	Hs
		881797 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SOX10_HUMAN (4-98): 1.42e-19: 87.9: 14.74
+	Hs
		817955 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91
+	Hs
		178916 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		TOX3_HUMAN (91-165): 2.47e-29: 116: 40.00
+	Hs
		980859 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SOX7_HUMAN (3-90): 3.17e-20: 89.4: 19.32
+	Hs
		817967 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SOX2_HUMAN (3-94): 4.01e-22: 93.6: 23.91
+	Hs
		567682 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		UBF1_HUMAN (10-158): 1.5e-09: 59: 23.60
+	Hs
		993604 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SOX17_HUMAN (7-90): 3.32e-20: 89.4: 19.05
+	Dm
		558375 GROU_DROME (2-163): 8.11e-60: 200: 54.44		DICH_DROME (8-101): 1.81e-24: 100: 24.47
+	Dm
		558384 GROU_DROME (2-163): 8.11e-60: 200: 54.44		PANG2_DROME (3-85): 1.14e-09: 59.4: 10.84