HitPredict

Interactor 1: TLE5 (P63002)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG)
Gene: TLE5

Interactor 2: SIX3 (Q62233)
Homeobox protein SIX3 (Sine oculis homeobox homolog 3)
Gene: SIX3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	12050133
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 197 Mm			1 333
+	Mm
		1143691 TLE4_MOUSE (2-191): 1.43e-112: 339: 68.59		SIX3_MOUSE (1-333): 3.9e-122: 356: 100.00
+	Hs
		311439 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SIX3_HUMAN (1-333): 8.43e-118: 345: 96.10
+	Hs
		311440 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SIX3_HUMAN (1-333): 8.43e-118: 345: 96.10
+	Hs
		315171 TLE4_HUMAN (2-191): 1.23e-112: 340: 68.59		SIX6_HUMAN (80-333): 3.12e-91: 274: 78.35
+	Mm
		1143964 TLE4_MOUSE (2-191): 1.43e-112: 339: 68.59		SIX6_MOUSE (80-333): 6.84e-89: 268: 75.98
+	Hs
		315169 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SIX6_HUMAN (80-333): 3.12e-91: 274: 78.35
+	Hs
		980654 TLE1_HUMAN (2-197): 2.33e-109: 331: 64.50		SIX2_HUMAN (80-306): 1.49e-89: 271: 60.79
+	Hs
		315170 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SIX6_HUMAN (80-333): 3.12e-91: 274: 78.35
+	Hs
		980756 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SIX1_HUMAN (80-329): 1.47e-90: 274: 55.12
+	Hs
		980881 TLE3_HUMAN (2-197): 1.05e-105: 322: 61.00		SIX2_HUMAN (80-306): 1.49e-89: 271: 60.79
+	Hs
		315172 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SIX6_HUMAN (80-333): 3.12e-91: 274: 78.35
+	Hs
		993432 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SIX1_HUMAN (80-329): 1.47e-90: 274: 55.12
+	Hs
		993614 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		SIX2_HUMAN (80-306): 1.49e-89: 271: 60.79
+	Mm
		925832 TLE5_MOUSE (1-197): 2.49e-103: 297: 100.00		SIX6_MOUSE (80-333): 6.84e-89: 268: 75.98
+	Hs
		1132994 Q5T3G3_HUMAN (2-197): 2.91e-98: 286: 61.43		SIX2_HUMAN (80-306): 1.49e-89: 271: 60.79
+	Dm
		558378 GROU_DROME (2-163): 8.11e-60: 200: 54.44		SO_DROME (81-288): 5.43e-81: 254: 59.62
+	Dm
		558386 GROU_DROME (2-163): 8.11e-60: 200: 54.44		OPTIX_DROME (59-332): 2.47e-75: 241: 58.93
+	Hs
		993567 TLE5_HUMAN (1-197): 2.87e-103: 297: 99.49		MEIS3_HUMAN (209-308): 6.08e-26: 108: 32.69
+	Ce
		137686 UNC37_CAEEL (18-166): 2.92e-43: 154: 27.33		HM32_CAEEL (47-329): 5.33e-67: 218: 43.05