HitPredict

Interactor 1: E9PLN6 (E9PLN6)
Eyes absent homolog (EC 3.1.3.48)
Gene: EYA4

Interactor 2: SIX2 (Q9NPC8)
Homeobox protein SIX2 (Sine oculis homeobox homolog 2)
Gene: SIX2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 616 Hs			1 291
+	Hs
		318733 EYA4_HUMAN (1-616): 0: 695: 94.52		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		92587 E9PLN6_HUMAN (1-616): 0: 697: 100.00		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		318622 EYA4_HUMAN (1-616): 0: 695: 94.52		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		1143690 EYA4_MOUSE (1-616): 0: 682: 96.59		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Hs
		318748 EYA4_HUMAN (1-616): 0: 695: 94.52		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Hs
		318670 EYA4_HUMAN (1-616): 0: 695: 94.52		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		1304296 EYA1_HUMAN (30-616): 0: 581: 70.12		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Hs
		118611 EYA2_HUMAN (101-616): 0: 580: 58.59		SIX2_HUMAN (1-291): 9e-95: 283: 100.00
+	Mm
		956886 EYA1_MOUSE (30-616): 0: 586: 69.73		SIX2_MOUSE (1-291): 2.19e-90: 272: 90.20
+	Mm
		956885 EYA1_MOUSE (30-616): 0: 586: 69.73		SIX1_MOUSE (1-291): 1.55e-86: 262: 71.53
+	Hs
		1074456 EYA1_HUMAN (30-616): 0: 581: 70.12		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Hs
		118562 EYA2_HUMAN (101-616): 0: 580: 58.59		SIX1_HUMAN (1-291): 3.65e-87: 263: 71.86
+	Mm
		956884 EYA1_MOUSE (30-616): 0: 586: 69.73		SIX4_MOUSE (5-290): 1.25e-69: 231: 44.44
+	Mm
		956887 EYA1_MOUSE (30-616): 0: 586: 69.73		SIX3_MOUSE (1-245): 3.44e-71: 224: 57.43
+	Hs
		1304297 EYA1_HUMAN (30-616): 0: 581: 70.12		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Hs
		118619 EYA2_HUMAN (101-616): 0: 580: 58.59		SIX4_HUMAN (5-290): 9.9e-69: 228: 44.52
+	Mm
		139225 EYA2_MOUSE (81-616): 0: 571: 55.62		SIX4_MOUSE (5-290): 1.25e-69: 231: 44.44
+	Mm
		936193 EYA1_MOUSE (30-616): 0: 586: 69.73		SIX5_MOUSE (1-263): 1.16e-60: 206: 45.87
+	Hs
		1230644 EYA1_HUMAN (30-616): 0: 581: 70.12		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66
+	Hs
		1230645 EYA3_HUMAN (56-616): 0: 552: 52.72		SIX5_HUMAN (2-263): 2.55e-58: 200: 45.66