HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: PP6R3 (Q5H9R7)
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)
Gene: PPP6R3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	34079125, 35044719
Identification Methods	proximity labelling technology, phage display
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 937 Hs			1 873
+	Hs
		1014025 AP1B1_HUMAN (1-937): 0: 888: 82.72		PP6R3_HUMAN (1-873): 0: 854: 100.00
+	Hs
		257172 AP2B1_HUMAN (1-937): 0: 926: 100.00		PP6R2_HUMAN (1-870): 0: 766: 45.79
+	Hs
		257175 AP1B1_HUMAN (1-937): 0: 888: 82.72		PP6R2_HUMAN (1-870): 0: 766: 45.79
+	Hs
		926056 AP2B1_HUMAN (1-937): 0: 926: 100.00		PP6R1_HUMAN (1-872): 0: 670: 44.00
+	Hs
		321563 AP2A1_HUMAN (11-932): 0: 634: 16.97		PP6R3_HUMAN (1-873): 0: 854: 100.00
+	Hs
		302165 AP2A2_HUMAN (11-933): 0: 600: 16.99		PP6R3_HUMAN (1-873): 0: 854: 100.00
+	Hs
		257152 AP2A1_HUMAN (11-932): 0: 634: 16.97		PP6R2_HUMAN (1-870): 0: 766: 45.79
+	Hs
		212577 AP1G1_HUMAN (11-808): 1.03e-173: 527: 17.57		PP6R2_HUMAN (1-870): 0: 766: 45.79
+	Hs
		203219 AP2B1_HUMAN (1-937): 0: 926: 100.00		SYNJ1_HUMAN (459-873): 3.44e-31: 134: 13.04
+	Hs
		203223 AP1B1_HUMAN (1-937): 0: 888: 82.72		SYNJ1_HUMAN (459-873): 3.44e-31: 134: 13.04
+	Hs
		1014106 AP1B1_HUMAN (1-937): 0: 888: 82.72		CABIN_HUMAN (613-873): 2.13e-24: 112: 14.56
+	Hs
		926047 AP2B1_HUMAN (1-937): 0: 926: 100.00		MAGL2_HUMAN (607-860): 1.48e-12: 73.8: 9.65
+	Hs
		203194 AP2A1_HUMAN (11-932): 0: 634: 16.97		SYNJ1_HUMAN (459-873): 3.44e-31: 134: 13.04
+	Rn
		1144064 Q66HM2_RAT (11-932): 0: 590: 16.38		SYNJ1_RAT (459-866): 2.81e-34: 144: 11.34