HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: ARH (Q5SW96)
Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein)
Gene: LDLRAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 0.60 0.737

The method score is based on:

Property Details
Experiments 16189514, 32296183, 27107012, 12221107, 25416956, unassigned1304
Identification Methods two hybrid, pull down, mammalian protein protein interaction trap, validated two hybrid, two hybrid pooling approach, barcode fusion genetics two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0009898 - cytoplasmic side of plasma membrane
GO:0030276 - clathrin binding
GO:0030669 - clathrin-coated endocytic vesicle membrane
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 937
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024