HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8)
Gene: PSMA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA~Proteasome_A_N
Common GO terms	GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 255
+	Dm
		820506 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Dm
		1181031 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Dm
		820495 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Sc
		597220 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		PSA7_YEAST (1-246): 4.1e-111: 322: 51.20
+	Dm
		1359221 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA3_DROME (1-252): 1.3e-108: 315: 57.54
+	Hs
		92605 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		92615 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		92604 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Dm
		1181022 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Hs
		572858 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA3_HUMAN (1-255): 5.2e-97: 285: 100.00
+	Hs
		572863 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA5_HUMAN (1-239): 4.52e-96: 283: 31.97
+	Hs
		572911 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA6_HUMAN (4-242): 1.96e-95: 281: 29.34
+	Hs
		572859 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA4_HUMAN (4-236): 5.31e-94: 278: 27.43
+	Hs
		156216 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA7_HUMAN (7-237): 4.58e-93: 275: 31.76
+	Dm
		1278637 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA5_DROME (1-240): 1.81e-96: 284: 27.94
+	Sp
		736968 PRS4_SCHPO (51-301): 4.94e-85: 264: 38.04		PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00
+	Dm
		611634 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA71_DROME (8-184): 2.38e-32: 120: 36.72
+	Dm
		611645 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA71_DROME (8-184): 2.38e-32: 120: 36.72
+	Sp
		144489 PRS6A_SCHPO (31-301): 7.89e-73: 232: 70.22		PSA4_SCHPO (6-189): 3.96e-35: 127: 40.00
+	Dm
		611654 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSA71_DROME (8-184): 2.38e-32: 120: 36.72