HitPredict

Interactor 1: AP2B1 (P63010)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: NUMBL (Q9Y6R0)
Numb-like protein (Numb-related protein) (Numb-R)
Gene: NUMBL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 937 Hs			1 609
+	Rn
		923852 AP2B1_RAT (1-937): 0: 926: 100.00		Q3MUI1_RAT (42-609): 2.79e-74: 250: 52.65
+	Hs
		833572 AP2B1_HUMAN (1-937): 0: 926: 100.00		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Hs
		925962 AP2B1_HUMAN (1-937): 0: 926: 100.00		ANS1A_HUMAN (7-259): 2.46e-57: 210: 20.23
+	Hs
		833587 AP1B1_HUMAN (1-937): 0: 888: 82.72		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Hs
		925893 AP2B1_HUMAN (1-937): 0: 926: 100.00		ARH_HUMAN (63-279): 5.82e-49: 174: 23.42
+	Hs
		253551 AP2B1_HUMAN (1-937): 0: 926: 100.00		CAPON_HUMAN (68-316): 6.44e-39: 151: 19.05
+	Hs
		1014028 AP1B1_HUMAN (1-937): 0: 888: 82.72		ARH_HUMAN (63-279): 5.82e-49: 174: 23.42
+	Hs
		925851 AP2B1_HUMAN (1-937): 0: 926: 100.00		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		203219 AP2B1_HUMAN (1-937): 0: 926: 100.00		SYNJ1_HUMAN (217-607): 6.26e-12: 70.9: 11.21
+	Hs
		203223 AP1B1_HUMAN (1-937): 0: 888: 82.72		SYNJ1_HUMAN (217-607): 6.26e-12: 70.9: 11.21
+	Ce
		283753 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		CED6_CAEEL (64-430): 7.43e-32: 131: 15.72
+	Hs
		321513 AP2A1_HUMAN (11-932): 0: 634: 16.97		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Rn
		577194 AP2A2_RAT (11-932): 0: 595: 16.50		Q3MUI1_RAT (42-609): 2.79e-74: 250: 52.65
+	Rn
		1109842 Q66HM2_RAT (11-932): 0: 590: 16.38		Q3MUI1_RAT (42-609): 2.79e-74: 250: 52.65
+	Hs
		302120 AP2A2_HUMAN (11-933): 0: 600: 16.99		NUMB_HUMAN (42-609): 2.54e-68: 235: 46.87
+	Mm
		567529 AP2A2_MOUSE (11-932): 0: 596: 16.50		ANS1B_MOUSE (7-256): 3.08e-59: 216: 21.32
+	Hs
		321528 AP2A1_HUMAN (11-932): 0: 634: 16.97		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		302137 AP2A2_HUMAN (11-933): 0: 600: 16.99		DAB2_HUMAN (72-603): 1.12e-31: 132: 12.83
+	Hs
		203194 AP2A1_HUMAN (11-932): 0: 634: 16.97		SYNJ1_HUMAN (217-607): 6.26e-12: 70.9: 11.21
+	Rn
		1144064 Q66HM2_RAT (11-932): 0: 590: 16.38		SYNJ1_RAT (195-594): 1.39e-09: 63.6: 11.71