HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSB2 (P49721)
Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)
Gene: PSMB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~Proteasome
Common GO terms	GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 201
+	Dm
		820480 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q7K148_DROME (2-198): 6.07e-66: 205: 22.34
+	Dm
		820515 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q9VJJ0_DROME (1-195): 3.77e-66: 203: 51.28
+	Dm
		820525 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q9VUJ1_DROME (4-199): 3.12e-64: 201: 19.90
+	Dm
		771287 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSA2_DROME (4-197): 4.6e-64: 199: 18.88
+	Hs
		92607 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB5_HUMAN (2-197): 1.96e-66: 206: 17.86
+	Hs
		92604 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA4_HUMAN (3-198): 5.76e-65: 202: 17.73
+	Hs
		92625 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB7_HUMAN (3-199): 1.32e-64: 202: 19.80
+	Hs
		92602 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86
+	Dm
		1178941 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		Q7K148_DROME (2-198): 6.07e-66: 205: 22.34
+	Dm
		1181046 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		Q9VJJ0_DROME (1-195): 3.77e-66: 203: 51.28
+	Hs
		572866 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB5_HUMAN (2-197): 1.96e-66: 206: 17.86
+	Dm
		1181055 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		Q9VUJ1_DROME (4-199): 3.12e-64: 201: 19.90
+	Dm
		771298 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSA2_DROME (4-197): 4.6e-64: 199: 18.88
+	Hs
		572859 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA4_HUMAN (3-198): 5.76e-65: 202: 17.73
+	Hs
		572857 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSA2_HUMAN (4-197): 1.04e-64: 201: 17.86
+	Hs
		572895 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB2_HUMAN (1-201): 5.46e-65: 200: 100.00
+	Hs
		92600 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42
+	Hs
		572853 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB1_HUMAN (3-198): 2.07e-57: 182: 23.42
+	Hs
		92606 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSB6_HUMAN (3-188): 2.95e-44: 148: 17.74
+	Hs
		572865 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSB6_HUMAN (3-188): 2.95e-44: 148: 17.74