HitPredict

Interactor 1: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Interactor 2: SYPL1 (Q16563)
Synaptophysin-like protein 1 (Pantophysin)
Gene: SYPL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0030141 - secretory granule GO:0030672 - synaptic vesicle membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 259
+	Hs
		1079326 VAMP3_HUMAN (26-98): 7.88e-25: 92: 91.78		SYPL1_HUMAN (1-259): 2.65e-154: 431: 100.00
+	Hs
		1083205 VAMP8_HUMAN (20-99): 2.06e-24: 90.9: 32.50		SYPL1_HUMAN (1-259): 2.65e-154: 431: 100.00
+	Hs
		439113 VAMP2_HUMAN (25-116): 9.9e-26: 94.7: 100.00		SYPH_HUMAN (7-256): 5.56e-138: 392: 42.63
+	Mm
		926338 VAMP2_MOUSE (25-116): 9.9e-26: 94.7: 100.00		SYPH_MOUSE (7-256): 7.51e-136: 387: 42.63
+	Rn
		431095 VAMP2_RAT (25-116): 9.9e-26: 94.7: 100.00		SYPH_RAT (12-256): 1.98e-135: 385: 43.09
+	Hs
		1079344 VAMP3_HUMAN (26-98): 7.88e-25: 92: 91.78		SYPL2_HUMAN (9-239): 1.03e-117: 339: 40.95