HitPredict

Interactor 1: VAMP2 (P63027)
Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2)
Gene: VAMP2

Interactor 2: MARH8 (Q5T0T0)
E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8)
Gene: MARCHF8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.50	0.553

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 116 Hs			1 291
+	Hs
		850572 VAMP7_HUMAN (3-96): 2.69e-30: 109: 31.31		MARH8_HUMAN (1-291): 1.77e-109: 320: 100.00
+	Hs
		850600 VAMP7_HUMAN (3-96): 2.69e-30: 109: 31.31		MARH2_HUMAN (48-257): 8.13e-49: 164: 25.82
+	Hs
		850578 VAMP7_HUMAN (3-96): 2.69e-30: 109: 31.31		MARH3_HUMAN (55-253): 1.93e-48: 163: 24.26
+	Rn
		1190 A0A096MJ99_RAT (18-106): 1.69e-27: 99.7: 32.58		MARH2_RAT (48-239): 2.59e-47: 160: 26.15
+	Hs
		231857 VAMP7_HUMAN (3-96): 2.69e-30: 109: 31.31		MARH6_HUMAN (72-212): 3.3e-29: 118: 28.37
+	Hs
		180945 YKT6_HUMAN (5-85): 5.79e-24: 92.4: 24.69		MARH5_HUMAN (80-240): 5.93e-34: 126: 18.97