HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	AAA~RPN7
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 389
+	Hs
		572957 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		820500 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		730263 PRS7_HUMAN (14-300): 2.33e-68: 220: 31.71		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Hs
		798666 PRS6B_HUMAN (9-301): 2.8e-68: 220: 34.13		PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00
+	Dm
		1358523 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Dm
		1358526 Q9V405_DROME (15-301): 4.18e-69: 222: 33.10		PSMD6_DROME (1-389): 2.36e-125: 368: 70.18
+	Hs
		572913 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		CSN2_HUMAN (22-388): 5.37e-90: 280: 13.67
+	Dm
		820482 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		92595 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Sc
		703852 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Dm
		1180706 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Sc
		703741 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		RPN7_YEAST (11-389): 3.41e-86: 269: 35.47
+	Hs
		121676 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Dm
		1180714 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Dm
		1180716 Q9V405_DROME (15-301): 4.18e-69: 222: 33.10		PSD11_DROME (7-387): 4.3e-77: 246: 13.32
+	Hs
		121699 PRS7_HUMAN (14-300): 2.33e-68: 220: 31.71		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	Hs
		121703 PRS6B_HUMAN (9-301): 2.8e-68: 220: 34.13		PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03
+	At
		1338955 PS6AA_ARATH (37-301): 8.82e-71: 226: 76.69		PSD11_ARATH (7-388): 4e-73: 235: 11.75
+	Sc
		703867 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57
+	Sc
		703763 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		RPN6_YEAST (30-389): 1.53e-56: 192: 12.57