HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: DUS2 (Q05922)
Dual specificity protein phosphatase 2 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PAC-1)
Gene: Dusp2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	16288922
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Mm			1 318
+	Hs
		658903 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS2_HUMAN (5-318): 6.56e-127: 366: 87.58
+	Hs
		647553 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS2_HUMAN (5-318): 6.56e-127: 366: 87.58
+	Hs
		658798 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS1_HUMAN (5-316): 5.8e-110: 325: 53.44
+	Hs
		658919 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS4_HUMAN (4-316): 3.07e-108: 322: 45.86
+	Hs
		647475 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS1_HUMAN (5-316): 5.8e-110: 325: 53.44
+	Hs
		647563 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS4_HUMAN (4-316): 3.07e-108: 322: 45.86
+	Hs
		658962 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS7_HUMAN (16-315): 1.3e-103: 311: 34.63
+	Hs
		659043 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS16_HUMAN (10-315): 1.36e-99: 308: 34.53
+	Hs
		658923 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS8_HUMAN (8-315): 9.16e-98: 302: 34.30
+	Hs
		658960 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS5_HUMAN (11-316): 3.3e-100: 301: 44.20
+	Mm
		926439 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		DUS6_MOUSE (10-315): 1.08e-96: 292: 32.47
+	Rn
		926496 MK01_RAT (1-358): 3.67e-159: 451: 100.00		DUS6_RAT (10-315): 2.34e-95: 288: 32.47
+	Hs
		658961 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS6_HUMAN (10-315): 1.01e-94: 287: 33.05
+	Hs
		659102 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS10_HUMAN (32-315): 9.01e-87: 270: 31.63
+	Hs
		659034 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS9_HUMAN (21-315): 2.05e-85: 263: 31.94
+	Hs
		659006 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS19_HUMAN (119-313): 1.05e-60: 194: 30.96
+	Mm
		926438 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		DUS3_MOUSE (179-315): 2.89e-21: 90.9: 36.05
+	Hs
		659008 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		STYX_HUMAN (179-312): 1.74e-20: 89.7: 40.14
+	Hs
		658858 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DUS3_HUMAN (179-315): 2.62e-20: 88.2: 35.37
+	Hs
		647521 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DUS3_HUMAN (179-315): 2.62e-20: 88.2: 35.37