HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0000165 - MAPK cascade GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0060291 - long-term synaptic potentiation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 358 Mm			1 1730
+	Mm
		1115944 MK03_MOUSE (13-355): 3.86e-153: 437: 88.34		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		659044 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Rn
		926518 MK01_RAT (1-358): 3.67e-159: 451: 100.00		CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84
+	Hs
		658865 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Mm
		926405 MK01_MOUSE (1-358): 3.67e-159: 451: 100.00		TNKS2_MOUSE (1-457): 3.41e-87: 313: 17.02
+	Hs
		659047 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		TNKS2_HUMAN (1-544): 1.02e-87: 315: 15.16
+	Hs
		647524 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		166888 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60
+	Mm
		814053 MK14_MOUSE (16-354): 7.69e-111: 329: 48.97		MIB1_MOUSE (187-684): 8.82e-51: 198: 10.36