HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	16517408, 20154642
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PB1~Pkinase
Common GO terms	GO:0005739 - mitochondrion GO:0005770 - late endosome GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 358 Mm			1 442
+	Mm
		1144377 MK03_MOUSE (13-355): 3.86e-153: 437: 88.34		SQSTM_MOUSE (1-442): 0: 777: 100.00
+	Hs
		658932 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		647573 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		1036609 MK14_HUMAN (16-354): 1.6e-111: 330: 48.97		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Ce
		764293 MPK1_CAEEL (10-355): 1.12e-143: 415: 79.77		Q17746_CAEEL (85-182): 4.79e-29: 120: 24.49
+	Mm
		814053 MK14_MOUSE (16-354): 7.69e-111: 329: 48.97		MIB1_MOUSE (105-228): 1.65e-27: 117: 27.69