HitPredict

Interactor 1: MK01 (P63085)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: Mapk1

Interactor 2: PAXI (Q8VI36)
Paxillin
Gene: Pxn

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	14636584, 15494312, 11784715, 10753946
Identification Methods	pull down, affinity chromatography technology, protein kinase assay, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005856 - cytoskeleton GO:0005925 - focal adhesion GO:0019901 - protein kinase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 358 Mm			1 591
+	Hs
		658847 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PAXI_HUMAN (12-591): 1.24e-140: 422: 93.62
+	Hs
		647508 MK03_HUMAN (3-356): 7.99e-154: 439: 85.88		LIMS1_HUMAN (346-529): 1.27e-42: 157: 32.97
+	Hs
		659065 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		PDLI7_HUMAN (473-590): 4.15e-32: 131: 33.90
+	Hs
		658936 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		FHL3_HUMAN (351-467): 8.93e-27: 111: 32.23
+	Hs
		658939 MK01_HUMAN (9-358): 5.56e-158: 448: 99.71		FHL2_HUMAN (348-467): 1.93e-23: 102: 29.03
+	Ce
		107584 MPK1_CAEEL (10-355): 1.12e-143: 415: 79.77		G5EFG1_CAEEL (473-590): 3.77e-15: 80.9: 35.00