HitPredict

Interactor 1: PP1G (P63087)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: Ppp1cc

Interactor 2: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	30562941, 20124353, 28634551, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Metallophos~PDZ, Metallophos~PDZ_5, PDZ~STPPase_N, PDZ_5~STPPase_N
Common GO terms	GO:0005737 - cytoplasm GO:0008157 - protein phosphatase 1 binding GO:0043197 - dendritic spine GO:0044877 - protein-containing complex binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 323 Mm			1 817
+	Rn
		192521 PP1G_RAT (1-323): 0: 601: 100.00		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Hs
		737997 PP1G_HUMAN (1-323): 0: 601: 99.69		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Rn
		192519 PP1A_RAT (1-323): 0: 578: 90.66		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		906288 PP1A_MOUSE (1-323): 0: 578: 90.36		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Hs
		906098 PP1A_HUMAN (1-323): 0: 578: 90.66		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Hs
		738120 PP1G_HUMAN (1-323): 0: 601: 99.69		NEB1_HUMAN (1-817): 1.2e-100: 338: 46.50
+	Rn
		192520 PP1B_RAT (1-322): 0: 559: 86.89		NEB2_RAT (1-817): 2.42e-118: 379: 98.90
+	Mm
		906654 PP1B_MOUSE (1-322): 0: 559: 86.89		NEB2_MOUSE (1-817): 1.3e-116: 374: 100.00
+	Hs
		906570 PP1B_HUMAN (1-322): 0: 559: 86.89		NEB2_HUMAN (1-817): 5.5e-113: 365: 95.84
+	Rn
		193534 PP1G_RAT (1-323): 0: 601: 100.00		NEB1_RAT (1-817): 1.17e-92: 316: 45.86
+	Hs
		906197 PP1A_HUMAN (1-323): 0: 578: 90.66		NEB1_HUMAN (1-817): 1.2e-100: 338: 46.50
+	Hs
		906629 PP1B_HUMAN (1-322): 0: 559: 86.89		NEB1_HUMAN (1-817): 1.2e-100: 338: 46.50
+	Rn
		193533 PP1B_RAT (1-322): 0: 559: 86.89		NEB1_RAT (1-817): 1.17e-92: 316: 45.86
+	Mm
		926531 PP1G_MOUSE (1-323): 0: 601: 100.00		DLG3_MOUSE (224-734): 1.59e-39: 159: 16.23
+	Hs
		737775 PP1G_HUMAN (1-323): 0: 601: 99.69		DLG1_HUMAN (80-763): 3.75e-33: 139: 11.22
+	Hs
		906059 PP1A_HUMAN (1-323): 0: 578: 90.66		DLG3_HUMAN (269-734): 1.64e-40: 162: 16.36
+	Hs
		906031 PP1A_HUMAN (1-323): 0: 578: 90.66		LNX1_HUMAN (224-773): 4.36e-33: 138: 11.92
+	Mm
		906274 PP1A_MOUSE (1-323): 0: 578: 90.36		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04
+	Hs
		905921 PP1A_HUMAN (1-323): 0: 578: 90.66		DLG2_HUMAN (413-817): 2.76e-25: 114: 14.35
+	Mm
		906652 PP1B_MOUSE (1-322): 0: 559: 86.89		DLG4_MOUSE (381-806): 1.83e-31: 133: 11.04