HitPredict

Interactor 1: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Interactor 2: GBG1 (P63211)
Guanine nucleotide-binding protein G(T) subunit gamma-T1 (Transducin gamma chain)
Gene: GNGT1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 394 Hs			1 74
+	Hs
		887098 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG2_HUMAN (16-73): 7.17e-24: 87: 39.66
+	Hs
		926563 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG3_HUMAN (16-73): 6.92e-24: 87: 37.93
+	Hs
		837688 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG10_HUMAN (14-73): 8.53e-24: 86.6: 33.33
+	Hs
		926564 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG5_HUMAN (14-73): 5.33e-23: 84.6: 28.33
+	Hs
		837674 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG4_HUMAN (16-73): 2.26e-22: 83.1: 37.93
+	Hs
		926657 GNAS2_HUMAN (1-394): 1.94e-179: 506: 100.00		GBG8_HUMAN (16-73): 5.31e-22: 81.9: 37.93
+	Hs
		229233 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21
+	Hs
		229239 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG7_HUMAN (16-73): 1.84e-24: 88.1: 36.21
+	Hs
		391364 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG2_HUMAN (16-73): 7.17e-24: 87: 39.66
+	Hs
		391377 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG3_HUMAN (16-73): 6.92e-24: 87: 37.93
+	Hs
		391360 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG10_HUMAN (14-73): 8.53e-24: 86.6: 33.33
+	Hs
		887099 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG2_HUMAN (16-73): 7.17e-24: 87: 39.66
+	Hs
		926667 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG3_HUMAN (16-73): 6.92e-24: 87: 37.93
+	Hs
		837689 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG10_HUMAN (14-73): 8.53e-24: 86.6: 33.33
+	Hs
		391378 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG5_HUMAN (14-73): 5.33e-23: 84.6: 28.33
+	Hs
		926668 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG5_HUMAN (14-73): 5.33e-23: 84.6: 28.33
+	Hs
		391359 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG4_HUMAN (16-73): 2.26e-22: 83.1: 37.93
+	Hs
		837675 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG4_HUMAN (16-73): 2.26e-22: 83.1: 37.93
+	Hs
		391482 GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83		GBG8_HUMAN (16-73): 5.31e-22: 81.9: 37.93
+	Hs
		926724 GNAI1_HUMAN (1-394): 5.37e-158: 450: 39.09		GBG8_HUMAN (16-73): 5.31e-22: 81.9: 37.93