HitPredict

Interactor 1: CANB1 (P63098)
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Gene: PPP3R1

Interactor 2: PP2BA (Q08209)
Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
Gene: PPP3CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25416956, 26186194, 21516116, 27880917, 28514442, 26871637, 32296183, 26264872, 33961781, 23468591, 22343722, 24954618, 8524402, unassigned1304, 32814053, 19896943
Identification Methods two hybrid, affinity chromatography technology, molecular sieving, pull down, light scattering, two hybrid prey pooling approach, two hybrid array, validated two hybrid, x-ray crystallography, anti tag coimmunoprecipitation and 1 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~Metallophos
Common GO terms GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005955 - calcineurin complex
and 13 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 170
Hs

1 521
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Ce
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Sc
+ Sc
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024