HitPredict

Interactor 1: 1433Z (P63101)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)
Gene: Ywhaz

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	27507650, 28671696, 29111324, 36417873, 28469556
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0044877 - protein-containing complex binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Mm			1 1730
+	Mm
		910247 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		933122 1433T_MOUSE (1-245): 8.98e-140: 393: 79.59		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		909986 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Mm
		1116099 1433B_MOUSE (1-242): 1.98e-128: 364: 86.78		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		905336 1433G_MOUSE (1-240): 8.4e-109: 315: 74.59		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		646746 1433T_HUMAN (1-245): 2.6e-140: 395: 80.00		DAPK1_HUMAN (17-450): 1.03e-87: 318: 15.97
+	Hs
		927522 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		883471 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		910023 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		883468 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		647273 1433T_HUMAN (1-245): 2.6e-140: 395: 80.00		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		646759 1433T_HUMAN (1-245): 2.6e-140: 395: 80.00		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		683708 1433B_HUMAN (1-242): 9.01e-140: 393: 88.02		Q9H4D1_HUMAN (1-279): 6.7e-66: 242: 18.21
+	Hs
		683234 1433B_HUMAN (1-242): 9.01e-140: 393: 88.02		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		683652 1433B_HUMAN (1-242): 9.01e-140: 393: 88.02		Q96T11_HUMAN (1-279): 4.2e-65: 239: 18.51
+	Hs
		883467 1433G_HUMAN (1-240): 8.4e-109: 315: 74.59		RIPK4_HUMAN (1-279): 5.68e-65: 240: 18.21
+	Hs
		926936 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		909455 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Hs
		646808 1433T_HUMAN (1-245): 2.6e-140: 395: 80.00		ANK2_HUMAN (212-349): 7.67e-29: 129: 24.64
+	Dr
		1193340 Q7ZUM0_DANRE (1-231): 2.06e-123: 352: 84.42		MIB1_DANRE (129-324): 1.65e-14: 81.6: 32.50