HitPredict

Interactor 1: 1433Z (P63101)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)
Gene: Ywhaz

Interactor 2: KSR1 (Q61097)
Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb)
Gene: KSR1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.726

Property	Details
Experiments	9115393, 9858547
Identification Methods	two hybrid, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Mm			1 873
+	Mm
		910254 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		KSR1_MOUSE (1-873): 0: 763: 100.00
+	Hs
		927270 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		KSR1_HUMAN (1-873): 0: 695: 85.17
+	Hs
		927188 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		KSR2_HUMAN (31-848): 3.41e-177: 538: 42.37
+	Hs
		927721 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		M3K4_HUMAN (29-826): 2.36e-170: 537: 18.90
+	Hs
		909702 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KSR2_HUMAN (31-848): 3.41e-177: 538: 42.37
+	Hs
		110870 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		H7C560_HUMAN (123-854): 7.65e-151: 464: 22.84
+	Gg
		982836 1433Z_CHICK (1-245): 7.65e-144: 403: 98.78		BRAF_CHICK (98-854): 1.25e-151: 466: 22.49
+	Gg
		982842 1433E_CHICK (2-241): 9.9e-144: 403: 68.18		BRAF_CHICK (98-854): 1.25e-151: 466: 22.49
+	Hs
		542857 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		BRAF_HUMAN (123-854): 1.9e-150: 463: 22.84
+	Hs
		110869 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		H7C560_HUMAN (123-854): 7.65e-151: 464: 22.84
+	Hs
		542849 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		BRAF_HUMAN (123-854): 1.9e-150: 463: 22.84
+	Mm
		655943 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		BRAF_MOUSE (123-854): 3.96e-146: 451: 22.46
+	Mm
		655938 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		BRAF_MOUSE (123-854): 3.96e-146: 451: 22.46
+	Hs
		374021 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		RAF1_HUMAN (240-858): 1.26e-144: 444: 24.45
+	Mm
		926872 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		RAF1_MOUSE (240-858): 9.08e-144: 441: 24.61
+	Hs
		373995 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		RAF1_HUMAN (240-858): 1.26e-144: 444: 24.45
+	Hs
		488665 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		ARAF_HUMAN (234-849): 1.06e-137: 424: 24.88
+	Hs
		488645 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ARAF_HUMAN (234-849): 1.06e-137: 424: 24.88
+	Hs
		411666 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		LCK_HUMAN (541-840): 8.67e-98: 317: 23.93
+	Hs
		411661 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		LCK_HUMAN (541-840): 8.67e-98: 317: 23.93