HitPredict

Interactor 1: 1433Z (P63101)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) (SEZ-2)
Gene: Ywhaz

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Mm			1 1161
+	Mm
		910338 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		TSC1_MOUSE (1-1161): 0: 771: 100.00
+	Hs
		927360 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		927241 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		PHLB1_HUMAN (281-916): 3.43e-37: 154: 14.88
+	Hs
		927643 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH2_HUMAN (370-1133): 2.91e-27: 122: 10.41
+	Hs
		522602 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH7_HUMAN (394-1133): 2.36e-26: 119: 8.63
+	Hs
		551660 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		DESP_HUMAN (548-1138): 1.55e-25: 117: 11.54
+	Hs
		724761 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH9_HUMAN (649-1160): 1.28e-25: 117: 10.68
+	Mm
		926886 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		MY18A_MOUSE (540-1147): 1.87e-24: 113: 10.97
+	Hs
		927145 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		502907 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH3_HUMAN (312-981): 2.28e-20: 100: 12.05
+	Hs
		927644 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH13_HUMAN (405-976): 2.04e-18: 93.7: 12.80
+	Mm
		926804 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		MYH10_MOUSE (708-1000): 6.45e-15: 82.3: 14.77
+	Mm
		93548 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		DESP_MOUSE (706-1133): 3.64e-15: 83.3: 12.56
+	Mm
		926855 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		MYH9_MOUSE (773-1161): 3.4e-11: 70.2: 11.72
+	Hs
		728466 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		MYH11_HUMAN (796-1161): 5.47e-11: 69.5: 12.30
+	Hs
		728460 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYH11_HUMAN (796-1161): 5.47e-11: 69.5: 12.30
+	Mm
		926889 1433Z_MOUSE (1-245): 3.48e-145: 407: 100.00		PLEC_MOUSE (557-1006): 2.01e-09: 64.5: 13.40
+	Hs
		725130 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MYH10_HUMAN (617-910): 9.54e-10: 65.3: 13.27
+	Hs
		926974 1433Z_HUMAN (1-245): 1.67e-144: 405: 99.59		CGNL1_HUMAN (722-989): 7.46e-09: 62.5: 21.07
+	Hs
		909488 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CGNL1_HUMAN (722-989): 7.46e-09: 62.5: 21.07