HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: FOXO4 (P98177)
Forkhead box protein O4 (Fork head domain transcription factor AFX1)
Gene: FOXO4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	14690436
Identification Methods	molecular sieving, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 505
+	Hs
		909442 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FOXO4_HUMAN (1-505): 4.98e-95: 299: 100.00
+	Hs
		68643 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FOXO6_HUMAN (8-502): 2.05e-71: 237: 36.38
+	Hs
		68644 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FOXO6_HUMAN (8-502): 2.05e-71: 237: 36.38
+	Hs
		206822 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		206820 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Dm
		664627 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		FOXO_DROME (16-501): 3.68e-64: 221: 29.48
+	Dm
		955013 1433E_DROME (2-242): 3.33e-143: 402: 66.67		FOXO_DROME (16-501): 3.68e-64: 221: 29.48
+	Hs
		46292 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		A0A1X9RU27_HUMAN (8-502): 1.67e-65: 223: 32.36
+	Hs
		206799 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		46293 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		A0A1X9RU27_HUMAN (8-502): 1.67e-65: 223: 32.36
+	Hs
		206807 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FOXO3_HUMAN (46-502): 3.73e-64: 222: 35.35
+	Hs
		926976 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		909490 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		646840 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FOXO1_HUMAN (23-502): 1.08e-55: 199: 34.59
+	Hs
		926921 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		909439 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		683226 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FOXA1_HUMAN (4-410): 8.56e-47: 171: 19.86
+	Hs
		646796 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		683265 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		FOXK1_HUMAN (5-443): 4.01e-43: 164: 19.39
+	Hs
		909499 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		FOXC1_HUMAN (70-237): 5.11e-40: 153: 27.93