HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	25852190, 9197417, 35271311, 12154078
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 496
+	Hs
		909448 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		646800 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		926925 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		909449 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		625334 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		625306 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		909447 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Hs
		625130 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		926960 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		909472 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		646799 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Dm
		955007 1433E_DROME (2-242): 3.33e-143: 402: 66.67		Q7KM03_DROME (4-479): 4.35e-136: 404: 43.81
+	Dm
		955011 1433E_DROME (2-242): 3.33e-143: 402: 66.67		Q94888_DROME (4-479): 1.48e-135: 402: 44.47
+	Hs
		300633 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841150 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		300632 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841132 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	At
		965298 14332_ARATH (3-239): 6.89e-143: 401: 65.15		MPK7_ARATH (152-490): 6.63e-132: 388: 31.79
+	Hs
		300626 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		646734 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69