HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: CDK17 (Q00537)
Cyclin-dependent kinase 17 (EC 2.7.11.22) (Cell division protein kinase 17) (PCTAIRE-motif protein kinase 2) (Serine/threonine-protein kinase PCTAIRE-2)
Gene: CDK17

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	33961781, 35271311, 36931259, 28514442, 15161933
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 523
+	Hs
		909449 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK17_HUMAN (1-523): 0: 544: 100.00
+	Hs
		646801 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK17_HUMAN (1-523): 0: 544: 100.00
+	Hs
		926924 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK16_HUMAN (1-513): 1.11e-158: 462: 69.20
+	Hs
		909448 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK16_HUMAN (1-513): 1.11e-158: 462: 69.20
+	Hs
		625334 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK2_HUMAN (189-484): 1.93e-160: 459: 52.35
+	Hs
		625306 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK2_HUMAN (189-484): 1.93e-160: 459: 52.35
+	Hs
		646800 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK16_HUMAN (1-513): 1.11e-158: 462: 69.20
+	Hs
		625130 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK2_HUMAN (189-484): 1.93e-160: 459: 52.35
+	Hs
		909447 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK3_HUMAN (189-492): 3.96e-152: 438: 50.98
+	Hs
		646799 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK3_HUMAN (189-492): 3.96e-152: 438: 50.98
+	Hs
		926960 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK18_HUMAN (54-522): 1.08e-145: 428: 66.31
+	Hs
		909472 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK18_HUMAN (54-522): 1.08e-145: 428: 66.31
+	Hs
		646826 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK18_HUMAN (54-522): 1.08e-145: 428: 66.31
+	At
		965298 14332_ARATH (3-239): 6.89e-143: 401: 65.15		MPK7_ARATH (161-519): 2.65e-138: 405: 30.06
+	Dm
		955007 1433E_DROME (2-242): 3.33e-143: 402: 66.67		Q7KM03_DROME (108-506): 5.01e-134: 400: 50.97
+	Dm
		955011 1433E_DROME (2-242): 3.33e-143: 402: 66.67		Q94888_DROME (87-506): 2.71e-134: 400: 48.50
+	Hs
		300633 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK14_HUMAN (164-520): 5.9e-131: 390: 53.89
+	Hs
		300632 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK14_HUMAN (164-520): 5.9e-131: 390: 53.89
+	Hs
		300626 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		CDK14_HUMAN (164-520): 5.9e-131: 390: 53.89
+	Hs
		300628 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		CDK14_HUMAN (164-520): 5.9e-131: 390: 53.89