HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	35271311, 27684187, 31980649, 17979178, unassigned2173
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0006468 - protein phosphorylation GO:0007165 - signal transduction and 1 others more... GO:0070371 - ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 393
+	Hs
		909461 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		647869 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647862 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Xl
		223344 O57468_XENLA (2-241): 8.77e-143: 401: 68.18		Q804T2_XENLA (1-333): 1.36e-120: 367: 19.94
+	Hs
		734907 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		734905 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		625334 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		625306 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		909447 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		CDK3_HUMAN (65-379): 5.96e-120: 351: 21.81
+	At
		965298 14332_ARATH (3-239): 6.89e-143: 401: 65.15		MPK7_ARATH (67-383): 1.52e-119: 352: 18.71
+	Dm
		664607 1433Z_DROME (1-245): 3.35e-143: 402: 81.22		DSOR1_DROME (12-392): 4.19e-114: 340: 61.42
+	Dm
		954998 1433E_DROME (2-242): 3.33e-143: 402: 66.67		DSOR1_DROME (12-392): 4.19e-114: 340: 61.42
+	Hs
		909502 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		STK4_HUMAN (37-369): 2.53e-111: 336: 30.06
+	Hs
		909512 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		STK3_HUMAN (50-369): 2.6e-109: 331: 33.23
+	Hs
		131562 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		STK25_HUMAN (50-367): 4.36e-103: 312: 31.88
+	Hs
		926998 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MP2K5_HUMAN (48-379): 4.35e-84: 265: 42.34
+	Hs
		805382 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69
+	Hs
		153111 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		MP2K7_HUMAN (35-375): 7.04e-61: 204: 35.49